Drug interactions
Amobarbital + Chlorzoxazone
Severity: Major
Amobarbital and Chlorzoxazone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amobarbital is a barbiturate with strong CNS depressant effects, and chlorzoxazone adds to sedation. The combination may produce profound drowsiness and respiratory depression. Barbiturates also induce liver enzymes, which may alter chlorzoxazone exposure.
What this interaction means in plain words
Amobarbital and Chlorzoxazone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amobarbital belongs to Central Nervous System; Chlorzoxazone belongs to Musculoskeletal.
Why it happens
Additive CNS and respiratory depression, plus barbiturate-mediated enzyme induction.
What to do
Avoid combining if possible; otherwise use low doses and monitor sedation and respiratory rate. Warn patients against alcohol and driving.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Chlorzoxazone
Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Frequently asked questions
Can I take Amobarbital with Chlorzoxazone?
MediHelp rates the interaction as major. Amobarbital and Chlorzoxazone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amobarbital is a barbiturate with strong CNS depressant effects, and chlorzoxazone adds to sedation. The combination may produce profound drowsiness and respiratory depression. Barbiturates also induce liver enzymes, which may alter chlorzoxazone exposure.
How serious is the interaction between Amobarbital and Chlorzoxazone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining if possible; otherwise use low doses and monitor sedation and respiratory rate. Warn patients against alcohol and driving.
What other medicines interact with Chlorzoxazone?
MediHelp also lists interactions of Chlorzoxazone with, for example, Alfentanil, Alprazolam, Belladonna and opium. The full list is on the Chlorzoxazone page.
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