Drug interactions
Benzhydrocodone / acetaminophen + Chlorzoxazone
Severity: Major
Benzhydrocodone / acetaminophen and Chlorzoxazone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids combined with muscle relaxants can cause profound sedation, respiratory depression, coma and death.
What this interaction means in plain words
Benzhydrocodone / acetaminophen and Chlorzoxazone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression through pharmacodynamic synergism.
What to do
Reserve for patients without adequate alternatives, use the lowest doses for the shortest time, and monitor for sedation and respiratory depression.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Chlorzoxazone
Frequently asked questions
Can I take Benzhydrocodone / acetaminophen with Chlorzoxazone?
MediHelp rates the interaction as major. Benzhydrocodone / acetaminophen and Chlorzoxazone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Opioids combined with muscle relaxants can cause profound sedation, respiratory depression, coma and death.
How serious is the interaction between Benzhydrocodone / acetaminophen and Chlorzoxazone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reserve for patients without adequate alternatives, use the lowest doses for the shortest time, and monitor for sedation and respiratory depression.
What other medicines interact with Chlorzoxazone?
MediHelp also lists interactions of Chlorzoxazone with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlorzoxazone page.
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