Drug interactions
Amoxapine + Cyclizine
Severity: Moderate
Amoxapine and Cyclizine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amoxapine is a tricyclic-type antidepressant with sedative and anticholinergic properties, as is cyclizine. Together they can cause additive drowsiness and anticholinergic effects including urinary retention, constipation, confusion and tachycardia.
What this interaction means in plain words
Amoxapine and Cyclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive muscarinic and H1 receptor blockade.
What to do
Monitor for oversedation and anticholinergic toxicity, particularly in older adults, and consider a non-anticholinergic antiemetic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Frequently asked questions
Can I take Amoxapine with Cyclizine?
MediHelp rates the interaction as moderate. Amoxapine and Cyclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amoxapine is a tricyclic-type antidepressant with sedative and anticholinergic properties, as is cyclizine. Together they can cause additive drowsiness and anticholinergic effects including urinary retention, constipation, confusion and tachycardia.
How serious is the interaction between Amoxapine and Cyclizine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and anticholinergic toxicity, particularly in older adults, and consider a non-anticholinergic antiemetic.
What other medicines interact with Cyclizine?
MediHelp also lists interactions of Cyclizine with, for example, Calcium / magnesium / potassium / sodium oxybates, Henbane, Sodium oxybate. The full list is on the Cyclizine page.
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