Drug interactions
Amoxapine + Flavoxate
Severity: Moderate
Amoxapine and Flavoxate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amoxapine has anticholinergic activity, and adding flavoxate can increase peripheral and central anticholinergic effects. These include urinary retention, constipation, dry mouth, tachycardia and confusion, especially in older adults.
What this interaction means in plain words
Amoxapine and Flavoxate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive muscarinic receptor antagonism.
What to do
Monitor for urinary retention, constipation, confusion and tachycardia. Reduce the dose or choose a less anticholinergic alternative if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flavoxate
- Clozapine + Flavoxate Major
- Abobotulinumtoxina + Flavoxate Moderate
- Aclidinium + Flavoxate Moderate
- Amantadine + Flavoxate Moderate
- Amitriptyline + Flavoxate Moderate
- Atropine iv / + Flavoxate Moderate
Frequently asked questions
Can I take Amoxapine with Flavoxate?
MediHelp rates the interaction as moderate. Amoxapine and Flavoxate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amoxapine has anticholinergic activity, and adding flavoxate can increase peripheral and central anticholinergic effects. These include urinary retention, constipation, dry mouth, tachycardia and confusion, especially in older adults.
How serious is the interaction between Amoxapine and Flavoxate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for urinary retention, constipation, confusion and tachycardia. Reduce the dose or choose a less anticholinergic alternative if symptoms develop.
What other medicines interact with Flavoxate?
MediHelp also lists interactions of Flavoxate with, for example, Clozapine, Abobotulinumtoxina, Aclidinium. The full list is on the Flavoxate page.
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