Drug interactions
Amitriptyline + Flavoxate
Severity: Moderate
Amitriptyline and Flavoxate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amitriptyline has marked anticholinergic activity, and flavoxate has antimuscarinic and smooth muscle relaxant effects. Together they may increase dry mouth, constipation, blurred vision, urinary retention and confusion, especially in older adults.
What this interaction means in plain words
Amitriptyline and Flavoxate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Flavoxate belongs to Genitourinary.
Why it happens
Additive antimuscarinic pharmacodynamic effects.
What to do
Monitor for anticholinergic effects and urinary retention; consider a less anticholinergic antidepressant in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flavoxate
- Clozapine + Flavoxate Major
- Abobotulinumtoxina + Flavoxate Moderate
- Aclidinium + Flavoxate Moderate
- Amantadine + Flavoxate Moderate
- Amoxapine + Flavoxate Moderate
- Atropine iv / + Flavoxate Moderate
Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Frequently asked questions
Can I take Amitriptyline with Flavoxate?
MediHelp rates the interaction as moderate. Amitriptyline and Flavoxate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amitriptyline has marked anticholinergic activity, and flavoxate has antimuscarinic and smooth muscle relaxant effects. Together they may increase dry mouth, constipation, blurred vision, urinary retention and confusion, especially in older adults.
How serious is the interaction between Amitriptyline and Flavoxate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects and urinary retention; consider a less anticholinergic antidepressant in older patients.
What other medicines interact with Flavoxate?
MediHelp also lists interactions of Flavoxate with, for example, Clozapine, Abobotulinumtoxina, Aclidinium. The full list is on the Flavoxate page.
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