Drug interactions
Atropine iv / + Flavoxate
Severity: Moderate
Atropine iv / and Flavoxate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atropine is a potent antimuscarinic and flavoxate has antimuscarinic effects, so together they can increase anticholinergic toxicity. This may cause tachycardia, urinary retention, dry mouth, hyperthermia and confusion.
What this interaction means in plain words
Atropine iv / and Flavoxate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive muscarinic receptor antagonism.
What to do
Monitor heart rate, urinary output, mental status and temperature. Consider holding flavoxate when atropine is given at higher doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flavoxate
- Clozapine + Flavoxate Major
- Abobotulinumtoxina + Flavoxate Moderate
- Aclidinium + Flavoxate Moderate
- Amantadine + Flavoxate Moderate
- Amitriptyline + Flavoxate Moderate
- Amoxapine + Flavoxate Moderate
Frequently asked questions
Can I take Atropine iv / with Flavoxate?
MediHelp rates the interaction as moderate. Atropine iv / and Flavoxate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atropine is a potent antimuscarinic and flavoxate has antimuscarinic effects, so together they can increase anticholinergic toxicity. This may cause tachycardia, urinary retention, dry mouth, hyperthermia and confusion.
How serious is the interaction between Atropine iv / and Flavoxate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, urinary output, mental status and temperature. Consider holding flavoxate when atropine is given at higher doses.
What other medicines interact with Flavoxate?
MediHelp also lists interactions of Flavoxate with, for example, Clozapine, Abobotulinumtoxina, Aclidinium. The full list is on the Flavoxate page.
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