Drug interactions
Amoxapine + Formoterol-mometasone
Severity: Major
Amoxapine and Formoterol-mometasone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amoxapine, a tricyclic antidepressant, can prolong QT and potentiate adrenergic cardiovascular effects, while formoterol is a beta-2 agonist that can cause tachycardia and QT lengthening. The combination may raise the risk of arrhythmia, particularly in patients with cardiac disease or electrolyte disturbances.
What this interaction means in plain words
Amoxapine and Formoterol-mometasone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QT prolongation, plus tricyclic inhibition of norepinephrine reuptake that may enhance sympathomimetic cardiovascular effects.
What to do
Formoterol labeling advises extreme caution with tricyclic antidepressants, so consider an alternative antidepressant or bronchodilator regimen. If both are needed, monitor ECG, heart rate and potassium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Formoterol-mometasone
Frequently asked questions
Can I take Amoxapine with Formoterol-mometasone?
MediHelp rates the interaction as major. Amoxapine and Formoterol-mometasone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amoxapine, a tricyclic antidepressant, can prolong QT and potentiate adrenergic cardiovascular effects, while formoterol is a beta-2 agonist that can cause tachycardia and QT lengthening. The combination may raise the risk of arrhythmia, particularly in patients with cardiac disease or electrolyte disturbances.
How serious is the interaction between Amoxapine and Formoterol-mometasone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Formoterol labeling advises extreme caution with tricyclic antidepressants, so consider an alternative antidepressant or bronchodilator regimen. If both are needed, monitor ECG, heart rate and potassium.
What other medicines interact with Formoterol-mometasone?
MediHelp also lists interactions of Formoterol-mometasone with, for example, Amiodarone, Amisulpride, Arformoterol. The full list is on the Formoterol-mometasone page.
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