Drug interactions
Amoxapine + Glycopyrronium
Severity: Moderate
Amoxapine and Glycopyrronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amoxapine has anticholinergic activity, so combining it with glycopyrronium adds to effects such as dry mouth, constipation, urinary retention, blurred vision and tachycardia. Elderly patients are especially vulnerable.
What this interaction means in plain words
Amoxapine and Glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects.
What to do
Monitor for anticholinergic toxicity, particularly urinary retention, constipation and confusion, and reduce doses or choose an alternative if troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glycopyrronium
- Clozapine + Glycopyrronium Major
- Abobotulinumtoxina + Glycopyrronium Moderate
- Aclidinium + Glycopyrronium Moderate
- Amantadine + Glycopyrronium Moderate
- Amitriptyline + Glycopyrronium Moderate
- Atropine iv / + Glycopyrronium Moderate
Frequently asked questions
Can I take Amoxapine with Glycopyrronium?
MediHelp rates the interaction as moderate. Amoxapine and Glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amoxapine has anticholinergic activity, so combining it with glycopyrronium adds to effects such as dry mouth, constipation, urinary retention, blurred vision and tachycardia. Elderly patients are especially vulnerable.
How serious is the interaction between Amoxapine and Glycopyrronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity, particularly urinary retention, constipation and confusion, and reduce doses or choose an alternative if troublesome.
What other medicines interact with Glycopyrronium?
MediHelp also lists interactions of Glycopyrronium with, for example, Clozapine, Abobotulinumtoxina, Aclidinium. The full list is on the Glycopyrronium page.
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