Drug interactions
Clozapine + Glycopyrronium
Severity: Major
Clozapine and Glycopyrronium: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clozapine has marked anticholinergic properties that add to those of glycopyrronium. This raises the risk of constipation, which with clozapine can progress to serious bowel obstruction or ileus, as well as urinary retention and tachycardia.
What this interaction means in plain words
Clozapine and Glycopyrronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clozapine belongs to Central Nervous System; Glycopyrronium belongs to Respiratory.
Why it happens
Additive antimuscarinic effects, with cumulative reduction of gastrointestinal motility.
What to do
Avoid the combination where possible; if used, monitor bowel function closely, use laxatives proactively, and stop glycopyrronium if constipation or retention develops.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Glycopyrronium
- Abobotulinumtoxina + Glycopyrronium Moderate
- Aclidinium + Glycopyrronium Moderate
- Amantadine + Glycopyrronium Moderate
- Amitriptyline + Glycopyrronium Moderate
- Amoxapine + Glycopyrronium Moderate
- Atropine iv / + Glycopyrronium Moderate
Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Clozapine with Glycopyrronium?
MediHelp rates the interaction as major. Clozapine and Glycopyrronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clozapine has marked anticholinergic properties that add to those of glycopyrronium. This raises the risk of constipation, which with clozapine can progress to serious bowel obstruction or ileus, as well as urinary retention and tachycardia.
How serious is the interaction between Clozapine and Glycopyrronium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if used, monitor bowel function closely, use laxatives proactively, and stop glycopyrronium if constipation or retention develops.
What other medicines interact with Glycopyrronium?
MediHelp also lists interactions of Glycopyrronium with, for example, Abobotulinumtoxina, Aclidinium, Amantadine. The full list is on the Glycopyrronium page.
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