Drug interactions
Amitriptyline + Glycopyrronium
Severity: Moderate
Amitriptyline and Glycopyrronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amitriptyline has substantial anticholinergic activity that adds to glycopyrronium. This can cause marked dry mouth, constipation, urinary retention, tachycardia and cognitive impairment.
What this interaction means in plain words
Amitriptyline and Glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Glycopyrronium belongs to Respiratory.
Why it happens
Additive antimuscarinic effects at cholinergic receptors.
What to do
Monitor for anticholinergic toxicity, especially in older adults or those with glaucoma or urinary obstruction, and consider an alternative antidepressant or lower doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glycopyrronium
- Clozapine + Glycopyrronium Major
- Abobotulinumtoxina + Glycopyrronium Moderate
- Aclidinium + Glycopyrronium Moderate
- Amantadine + Glycopyrronium Moderate
- Amoxapine + Glycopyrronium Moderate
- Atropine iv / + Glycopyrronium Moderate
Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Frequently asked questions
Can I take Amitriptyline with Glycopyrronium?
MediHelp rates the interaction as moderate. Amitriptyline and Glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amitriptyline has substantial anticholinergic activity that adds to glycopyrronium. This can cause marked dry mouth, constipation, urinary retention, tachycardia and cognitive impairment.
How serious is the interaction between Amitriptyline and Glycopyrronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity, especially in older adults or those with glaucoma or urinary obstruction, and consider an alternative antidepressant or lower doses.
What other medicines interact with Glycopyrronium?
MediHelp also lists interactions of Glycopyrronium with, for example, Clozapine, Abobotulinumtoxina, Aclidinium. The full list is on the Glycopyrronium page.
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