Drug interactions
Amoxapine + Hydrocodone
Severity: Moderate
Amoxapine and Hydrocodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amoxapine can add to opioid sedation and respiratory depression. Serotonin syndrome is possible with opioids and antidepressants that affect serotonin reuptake, and amoxapine also has anticholinergic effects.
What this interaction means in plain words
Amoxapine and Hydrocodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and possible serotonergic effects from norepinephrine and serotonin reuptake inhibition.
What to do
Use the lowest effective doses and monitor for sedation, respiratory depression and signs of serotonin toxicity such as agitation, tremor and hyperthermia. Take particular care when starting or increasing either drug.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocodone
- Alvimopan + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Hydrocodone + Isocarboxazid Contraindicated
- Hydrocodone + Olanzapine / samidorphan Contraindicated
- Hydrocodone + Phenelzine Contraindicated
- Alfentanil + Hydrocodone Major
Frequently asked questions
Can I take Amoxapine with Hydrocodone?
MediHelp rates the interaction as moderate. Amoxapine and Hydrocodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amoxapine can add to opioid sedation and respiratory depression. Serotonin syndrome is possible with opioids and antidepressants that affect serotonin reuptake, and amoxapine also has anticholinergic effects.
How serious is the interaction between Amoxapine and Hydrocodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for sedation, respiratory depression and signs of serotonin toxicity such as agitation, tremor and hyperthermia. Take particular care when starting or increasing either drug.
What other medicines interact with Hydrocodone?
MediHelp also lists interactions of Hydrocodone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydrocodone page.
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