Drug interactions
Bupropion-naltrexone + Hydrocodone
Severity: Contraindicated
Bupropion-naltrexone and Hydrocodone: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Naltrexone is an opioid antagonist and blocks the analgesic effect of hydrocodone, and can precipitate withdrawal in opioid-dependent patients. Bupropion also inhibits CYP2D6 and may reduce conversion of hydrocodone to hydromorphone, and the combination carries seizure and serotonergic concerns.
What this interaction means in plain words
Bupropion-naltrexone and Hydrocodone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Bupropion-naltrexone belongs to Miscellaneous; Hydrocodone belongs to Musculoskeletal.
Why it happens
Naltrexone competitively antagonizes opioid receptors; bupropion inhibits CYP2D6 and lowers seizure threshold.
What to do
Avoid combining; the bupropion-naltrexone product is contraindicated with chronic opioid use. Allow an opioid-free interval of 7 to 10 days before starting it.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Bupropion-naltrexone
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Bupropion-naltrexone + Isocarboxazid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion-naltrexone + Phenelzine Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion-naltrexone + Selegiline Contraindicated
Other interactions of Hydrocodone
- Alvimopan + Hydrocodone Contraindicated
- Hydrocodone + Isocarboxazid Contraindicated
- Hydrocodone + Olanzapine / samidorphan Contraindicated
- Hydrocodone + Phenelzine Contraindicated
- Alfentanil + Hydrocodone Major
- Alprazolam + Hydrocodone Major
Frequently asked questions
Can I take Bupropion-naltrexone with Hydrocodone?
MediHelp rates the interaction as contraindicated. Bupropion-naltrexone and Hydrocodone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Naltrexone is an opioid antagonist and blocks the analgesic effect of hydrocodone, and can precipitate withdrawal in opioid-dependent patients. Bupropion also inhibits CYP2D6 and may reduce conversion of hydrocodone to hydromorphone, and the combination carries seizure and serotonergic concerns.
How serious is the interaction between Bupropion-naltrexone and Hydrocodone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining; the bupropion-naltrexone product is contraindicated with chronic opioid use. Allow an opioid-free interval of 7 to 10 days before starting it.
What other medicines interact with Bupropion-naltrexone?
MediHelp also lists interactions of Bupropion-naltrexone with, for example, Hydromorphone, Isocarboxazid, Linezolid. The full list is on the Bupropion-naltrexone page.
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