Drug interactions
Amoxapine + Levetiracetam
Severity: Moderate
Amoxapine and Levetiracetam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amoxapine is sedating and can lower the seizure threshold, while levetiracetam also causes somnolence. The combination may increase drowsiness and may work against seizure control.
What this interaction means in plain words
Amoxapine and Levetiracetam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression, plus a pharmacodynamic opposition from amoxapine's proconvulsant effect.
What to do
Monitor seizure frequency and sedation, and use the lowest effective amoxapine dose. Consider an antidepressant with lower seizure risk in patients with epilepsy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levetiracetam
Frequently asked questions
Can I take Amoxapine with Levetiracetam?
MediHelp rates the interaction as moderate. Amoxapine and Levetiracetam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amoxapine is sedating and can lower the seizure threshold, while levetiracetam also causes somnolence. The combination may increase drowsiness and may work against seizure control.
How serious is the interaction between Amoxapine and Levetiracetam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure frequency and sedation, and use the lowest effective amoxapine dose. Consider an antidepressant with lower seizure risk in patients with epilepsy.
What other medicines interact with Levetiracetam?
MediHelp also lists interactions of Levetiracetam with, for example, Oliceridine, Opium tincture, Sodium oxybate. The full list is on the Levetiracetam page.
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