Drug interactions
Levetiracetam + Oliceridine
Severity: Major
Levetiracetam and Oliceridine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oliceridine is an opioid and its sedative and respiratory depressant effects may be potentiated by other CNS depressants. Levetiracetam adds to somnolence, so profound sedation is possible.
What this interaction means in plain words
Levetiracetam and Oliceridine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Levetiracetam belongs to Central Nervous System; Oliceridine belongs to Musculoskeletal.
Why it happens
Additive central nervous system and respiratory depression (pharmacodynamic).
What to do
Use the lowest effective oliceridine dose and monitor sedation level and respiratory rate. Reduce the opioid dose if excessive sedation occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Levetiracetam
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Levetiracetam with Oliceridine?
MediHelp rates the interaction as major. Levetiracetam and Oliceridine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oliceridine is an opioid and its sedative and respiratory depressant effects may be potentiated by other CNS depressants. Levetiracetam adds to somnolence, so profound sedation is possible.
How serious is the interaction between Levetiracetam and Oliceridine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective oliceridine dose and monitor sedation level and respiratory rate. Reduce the opioid dose if excessive sedation occurs.
What other medicines interact with Levetiracetam?
MediHelp also lists interactions of Levetiracetam with, for example, Opium tincture, Sodium oxybate, Sufentanil. The full list is on the Levetiracetam page.
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