Drug interactions
Levetiracetam + Sufentanil
Severity: Major
Levetiracetam and Sufentanil: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sufentanil is a very potent opioid that causes sedation and respiratory depression. Levetiracetam adds to drowsiness, increasing the risk of profound CNS depression.
What this interaction means in plain words
Levetiracetam and Sufentanil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Levetiracetam belongs to Central Nervous System; Sufentanil belongs to Musculoskeletal.
Why it happens
Additive central nervous system and respiratory depression (pharmacodynamic).
What to do
Use the lowest effective sufentanil dose and monitor sedation and respiratory function continuously in monitored settings.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Levetiracetam
Other interactions of Sufentanil
- Alprazolam + Sufentanil Major
- Amitriptyline + Sufentanil Major
- Amobarbital + Sufentanil Major
- Aripiprazole + Sufentanil Major
- Asenapine + Sufentanil Major
- Baclofen + Sufentanil Major
Frequently asked questions
Can I take Levetiracetam with Sufentanil?
MediHelp rates the interaction as major. Levetiracetam and Sufentanil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sufentanil is a very potent opioid that causes sedation and respiratory depression. Levetiracetam adds to drowsiness, increasing the risk of profound CNS depression.
How serious is the interaction between Levetiracetam and Sufentanil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective sufentanil dose and monitor sedation and respiratory function continuously in monitored settings.
What other medicines interact with Levetiracetam?
MediHelp also lists interactions of Levetiracetam with, for example, Oliceridine, Opium tincture, Sodium oxybate. The full list is on the Levetiracetam page.
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