Drug interactions
Amoxapine + Levothyroxine
Severity: Moderate
Amoxapine and Levothyroxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thyroid hormone can increase sensitivity to catecholamines, and tricyclic antidepressants such as amoxapine may potentiate this. The combination can increase the risk of tachyarrhythmias and CNS stimulation, and can also speed the antidepressant response.
What this interaction means in plain words
Amoxapine and Levothyroxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Thyroid hormone increases adrenergic receptor sensitivity, adding to the noradrenergic effects of the tricyclic antidepressant.
What to do
Monitor heart rate, rhythm and mental status, particularly when starting or changing the levothyroxine dose. Keep thyroid status in the euthyroid range.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levothyroxine
Frequently asked questions
Can I take Amoxapine with Levothyroxine?
MediHelp rates the interaction as moderate. Amoxapine and Levothyroxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thyroid hormone can increase sensitivity to catecholamines, and tricyclic antidepressants such as amoxapine may potentiate this. The combination can increase the risk of tachyarrhythmias and CNS stimulation, and can also speed the antidepressant response.
How serious is the interaction between Amoxapine and Levothyroxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, rhythm and mental status, particularly when starting or changing the levothyroxine dose. Keep thyroid status in the euthyroid range.
What other medicines interact with Levothyroxine?
MediHelp also lists interactions of Levothyroxine with, for example, Cholestyramine, Sodium iodide i-131, Tiratricol. The full list is on the Levothyroxine page.
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