Drug interactions
Amoxapine + Memantine-donepezil
Severity: Moderate
Amoxapine and Memantine-donepezil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both donepezil and amoxapine can prolong the QT interval. Combined use may increase the risk of torsades de pointes, especially with electrolyte disturbances or heart disease.
What this interaction means in plain words
Amoxapine and Memantine-donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation through cardiac repolarization effects.
What to do
Obtain a baseline ECG and correct potassium and magnesium before combining. Monitor QTc and consider an alternative antidepressant if QTc lengthens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amiodarone + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
Frequently asked questions
Can I take Amoxapine with Memantine-donepezil?
MediHelp rates the interaction as moderate. Amoxapine and Memantine-donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both donepezil and amoxapine can prolong the QT interval. Combined use may increase the risk of torsades de pointes, especially with electrolyte disturbances or heart disease.
How serious is the interaction between Amoxapine and Memantine-donepezil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium before combining. Monitor QTc and consider an alternative antidepressant if QTc lengthens.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
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