Drug interactions
Amoxapine + Metaxalone
Severity: Moderate
Amoxapine and Metaxalone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amoxapine is a sedating antidepressant and metaxalone adds CNS depression, which can cause drowsiness and impaired alertness. Metaxalone has also been linked to serotonin syndrome with serotonergic drugs, though amoxapine has weaker serotonergic effects.
What this interaction means in plain words
Amoxapine and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression; a minor possible serotonergic contribution.
What to do
Monitor for sedation and, at treatment start, for agitation, tremor or fever suggesting serotonin toxicity. Adjust doses if impairment occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metaxalone
Frequently asked questions
Can I take Amoxapine with Metaxalone?
MediHelp rates the interaction as moderate. Amoxapine and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amoxapine is a sedating antidepressant and metaxalone adds CNS depression, which can cause drowsiness and impaired alertness. Metaxalone has also been linked to serotonin syndrome with serotonergic drugs, though amoxapine has weaker serotonergic effects.
How serious is the interaction between Amoxapine and Metaxalone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and, at treatment start, for agitation, tremor or fever suggesting serotonin toxicity. Adjust doses if impairment occurs.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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