Drug interactions
Amoxapine + Naratriptan
Severity: Moderate
Amoxapine and Naratriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amoxapine inhibits reuptake of serotonin and norepinephrine, so combining it with a triptan could rarely lead to serotonin syndrome. Evidence is limited and the risk is low.
What this interaction means in plain words
Amoxapine and Naratriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic effects from triptan receptor agonism and amoxapine reuptake inhibition.
What to do
Monitor for serotonin syndrome features after starting or increasing either drug. Discontinue the serotonergic agents if it is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Naratriptan
- Almotriptan + Naratriptan Contraindicated
- Dihydroergotamine intranasal + Naratriptan Contraindicated
- Dihydroergotamine + Naratriptan Contraindicated
- Eletriptan + Naratriptan Contraindicated
- Ergoloid mesylates + Naratriptan Contraindicated
- Ergotamine + Naratriptan Contraindicated
Frequently asked questions
Can I take Amoxapine with Naratriptan?
MediHelp rates the interaction as moderate. Amoxapine and Naratriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amoxapine inhibits reuptake of serotonin and norepinephrine, so combining it with a triptan could rarely lead to serotonin syndrome. Evidence is limited and the risk is low.
How serious is the interaction between Amoxapine and Naratriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for serotonin syndrome features after starting or increasing either drug. Discontinue the serotonergic agents if it is suspected.
What other medicines interact with Naratriptan?
MediHelp also lists interactions of Naratriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Naratriptan page.
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