Drug interactions
Amoxapine + Secobarbital
Severity: Moderate
Amoxapine and Secobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the CNS, so combined use increases drowsiness and psychomotor impairment. Barbiturates may also lower tricyclic levels through enzyme induction, while amoxapine can lower the seizure threshold.
What this interaction means in plain words
Amoxapine and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression, plus barbiturate induction of hepatic enzymes that may reduce antidepressant exposure.
What to do
Counsel patients about sedation and avoid driving or alcohol. Monitor antidepressant response and adjust the amoxapine dose if efficacy falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Frequently asked questions
Can I take Amoxapine with Secobarbital?
MediHelp rates the interaction as moderate. Amoxapine and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the CNS, so combined use increases drowsiness and psychomotor impairment. Barbiturates may also lower tricyclic levels through enzyme induction, while amoxapine can lower the seizure threshold.
How serious is the interaction between Amoxapine and Secobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about sedation and avoid driving or alcohol. Monitor antidepressant response and adjust the amoxapine dose if efficacy falls.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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