Drug interactions
Amoxapine + Sertraline
Severity: Major
Amoxapine and Sertraline: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs raise serotonergic and noradrenergic activity, so combining them can lead to serotonin syndrome. Sertraline may also modestly raise amoxapine levels through CYP2D6 inhibition, which adds to the risk of anticholinergic and cardiac effects.
What this interaction means in plain words
Amoxapine and Sertraline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive serotonergic activity with reuptake inhibition, and CYP2D6 inhibition by sertraline.
What to do
Avoid combining unless clearly needed. If used together, start at low doses, monitor for serotonin toxicity and check an ECG if the dose is increased.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Amoxapine with Sertraline?
MediHelp rates the interaction as major. Amoxapine and Sertraline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs raise serotonergic and noradrenergic activity, so combining them can lead to serotonin syndrome. Sertraline may also modestly raise amoxapine levels through CYP2D6 inhibition, which adds to the risk of anticholinergic and cardiac effects.
How serious is the interaction between Amoxapine and Sertraline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining unless clearly needed. If used together, start at low doses, monitor for serotonin toxicity and check an ECG if the dose is increased.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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