Drug reference
sertraline
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Central Nervous System (SSRIs)
Mechanism of action
Selective serotonin reuptake inhibitor; little or no affinity for alpha-adrenergic histamine or cholinergic receptor
Common side effects
- Insomnia
- Dry mouth
- Dizziness
- Somnolence
- Fatigue
- Nausea
- Diarrhea/loose stools
Known interactions (14)
- isocarboxazid + sertraline Contraindicated
- selegiline + sertraline Contraindicated
- aspirin + sertraline Major
- desmopressin + sertraline Major
- dronedarone + sertraline Major
- fluvoxamine + sertraline Major
- linezolid + sertraline Major
- procarbazine + sertraline Major
- flibanserin + sertraline Moderate
- Gliclazide + sertraline Moderate
- Mirtazapine + sertraline Moderate
- Modafinil + sertraline Moderate
- Nebivolol + sertraline Moderate
- risperidone + sertraline Moderate
Related conditions
Frequently asked questions
What drug class is sertraline?
sertraline belongs to: Central Nervous System.
How does sertraline work?
Selective serotonin reuptake inhibitor; little or no affinity for alpha-adrenergic histamine or cholinergic receptor
What are the common side effects of sertraline?
Insomnia, Dry mouth, Dizziness, Somnolence, Fatigue, Nausea, Diarrhea/loose stools
Which drugs interact with sertraline?
isocarboxazid, selegiline, aspirin, desmopressin, dronedarone, fluvoxamine, linezolid, procarbazine, flibanserin, Gliclazide, Mirtazapine, Modafinil, Nebivolol, risperidone
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.