Drug interactions
selegiline + sertraline
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Serotonin syndrome risk; contraindicated (MAOI).
Mechanism of action
MAO inhibition + SSRI.
Clinical management
Contraindicated; observe washout periods.
Drug reference
References
Frequently asked questions
Can I take selegiline with sertraline?
The interaction is rated: Contraindicated. Serotonin syndrome risk; contraindicated (MAOI).
How serious is the interaction between selegiline and sertraline?
The interaction is rated: Contraindicated. Evidence level: High.
How is the interaction between selegiline and sertraline managed?
Contraindicated; observe washout periods.
Why do selegiline and sertraline interact?
MAO inhibition + SSRI.
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