Drug interactions
Amoxapine + Terbinafine
Severity: Moderate
Amoxapine and Terbinafine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Terbinafine is a strong CYP2D6 inhibitor and can raise amoxapine and its active metabolite levels. This may increase anticholinergic, sedative, cardiac and seizure risks.
What this interaction means in plain words
Amoxapine and Terbinafine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Terbinafine inhibits CYP2D6, reducing the metabolism of amoxapine.
What to do
Monitor for tricyclic adverse effects and consider reducing the amoxapine dose; obtain an ECG or drug levels if symptoms arise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Terbinafine
- Terbinafine + Thioridazine Contraindicated
- Desipramine + Terbinafine Major
- Eliglustat + Terbinafine Major
- Flecainide + Terbinafine Major
- Imipramine + Terbinafine Major
- Maprotiline + Terbinafine Major
Frequently asked questions
Can I take Amoxapine with Terbinafine?
MediHelp rates the interaction as moderate. Amoxapine and Terbinafine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Terbinafine is a strong CYP2D6 inhibitor and can raise amoxapine and its active metabolite levels. This may increase anticholinergic, sedative, cardiac and seizure risks.
How serious is the interaction between Amoxapine and Terbinafine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tricyclic adverse effects and consider reducing the amoxapine dose; obtain an ECG or drug levels if symptoms arise.
What other medicines interact with Terbinafine?
MediHelp also lists interactions of Terbinafine with, for example, Thioridazine, Desipramine, Eliglustat. The full list is on the Terbinafine page.
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