Drug interactions
Eliglustat + Terbinafine
Severity: Major
Eliglustat and Terbinafine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eliglustat is mainly metabolized by CYP2D6, and terbinafine strongly inhibits it. Raised eliglustat levels may prolong PR, QRS and QT intervals and cause arrhythmia.
What this interaction means in plain words
Eliglustat and Terbinafine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eliglustat belongs to Miscellaneous; Terbinafine belongs to Anti Fungals.
Why it happens
Terbinafine inhibits CYP2D6, markedly increasing eliglustat exposure.
What to do
Reduce eliglustat to the labeled lower dose in extensive metabolizers and monitor ECG; avoid it if other CYP3A inhibitors are also used.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Terbinafine
- Terbinafine + Thioridazine Contraindicated
- Desipramine + Terbinafine Major
- Flecainide + Terbinafine Major
- Imipramine + Terbinafine Major
- Maprotiline + Terbinafine Major
- Metoclopramide intranasal + Terbinafine Major
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Eliglustat with Terbinafine?
MediHelp rates the interaction as major. Eliglustat and Terbinafine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Eliglustat is mainly metabolized by CYP2D6, and terbinafine strongly inhibits it. Raised eliglustat levels may prolong PR, QRS and QT intervals and cause arrhythmia.
How serious is the interaction between Eliglustat and Terbinafine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce eliglustat to the labeled lower dose in extensive metabolizers and monitor ECG; avoid it if other CYP3A inhibitors are also used.
What other medicines interact with Terbinafine?
MediHelp also lists interactions of Terbinafine with, for example, Thioridazine, Desipramine, Flecainide. The full list is on the Terbinafine page.
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