Drug interactions
Amoxapine + Tolbutamide
Severity: Minor
Amoxapine and Tolbutamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic-type antidepressants have occasionally been associated with changes in glucose control and potentiation of sulfonylurea hypoglycemia. The evidence for amoxapine is sparse and the effect is probably small.
What this interaction means in plain words
Amoxapine and Tolbutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive effect on glucose lowering; the mechanism is not clearly established.
What to do
Monitor blood glucose when amoxapine is started or stopped in a patient on tolbutamide. Adjust the sulfonylurea dose if control changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Frequently asked questions
Can I take Amoxapine with Tolbutamide?
MediHelp rates the interaction as minor. Amoxapine and Tolbutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tricyclic-type antidepressants have occasionally been associated with changes in glucose control and potentiation of sulfonylurea hypoglycemia. The evidence for amoxapine is sparse and the effect is probably small.
How serious is the interaction between Amoxapine and Tolbutamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when amoxapine is started or stopped in a patient on tolbutamide. Adjust the sulfonylurea dose if control changes.
What other medicines interact with Tolbutamide?
MediHelp also lists interactions of Tolbutamide with, for example, Glyburide-metformin, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolbutamide page.
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