Drug interactions
Glyburide-metformin + Tolbutamide
Severity: Major
Glyburide-metformin and Tolbutamide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are sulfonylureas, so combining them adds to glucose-lowering and increases hypoglycemia risk without clear benefit. This is therapeutic duplication.
What this interaction means in plain words
Glyburide-metformin and Tolbutamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Glyburide-metformin belongs to Endocrine; Tolbutamide belongs to Endocrine.
Why it happens
Additive stimulation of pancreatic insulin secretion, with possible competition for CYP2C9 metabolism.
What to do
Avoid using two sulfonylureas together; use one agent and adjust its dose. Consider another drug class if more control is needed.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Glyburide-metformin
Other interactions of Tolbutamide
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
- Alogliptin-metformin + Tolbutamide Moderate
Frequently asked questions
Can I take Glyburide-metformin with Tolbutamide?
MediHelp rates the interaction as major. Glyburide-metformin and Tolbutamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both are sulfonylureas, so combining them adds to glucose-lowering and increases hypoglycemia risk without clear benefit. This is therapeutic duplication.
How serious is the interaction between Glyburide-metformin and Tolbutamide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two sulfonylureas together; use one agent and adjust its dose. Consider another drug class if more control is needed.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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