Drug interactions
Amoxapine + Ziprasidone
Severity: Major
Amoxapine and Ziprasidone: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amoxapine has dopamine-blocking activity through its metabolite 7-hydroxyamoxapine, so combining it with ziprasidone adds to the total dopamine antagonism. This raises the risk of extrapyramidal symptoms, tardive dyskinesia and neuroleptic malignant syndrome. Both drugs can also prolong the QT interval and cause sedation and hypotension.
What this interaction means in plain words
Amoxapine and Ziprasidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive dopamine D2 receptor blockade, with additional additive QT-prolonging and sedative effects.
What to do
Avoid the combination where possible and choose an antidepressant without dopamine-blocking activity. If used together, monitor for movement disorders, fever, rigidity and ECG changes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amoxapine and Ziprasidone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
References
Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Amoxapine with Ziprasidone?
MediHelp rates the interaction as major. Amoxapine and Ziprasidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amoxapine has dopamine-blocking activity through its metabolite 7-hydroxyamoxapine, so combining it with ziprasidone adds to the total dopamine antagonism. This raises the risk of extrapyramidal symptoms, tardive dyskinesia and neuroleptic malignant syndrome. Both drugs can also prolong the QT interval and cause sedation and hypotension.
How serious is the interaction between Amoxapine and Ziprasidone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and choose an antidepressant without dopamine-blocking activity. If used together, monitor for movement disorders, fever, rigidity and ECG changes.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
