Drug interactions
Amoxicillin-clavulanic acid + Aspirin
Severity: Minor
Amoxicillin-clavulanic acid and Aspirin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salicylates can compete with penicillins for renal tubular secretion and protein binding, which may modestly raise amoxicillin levels. The clinical effect is generally small given the wide therapeutic index of amoxicillin.
What this interaction means in plain words
Amoxicillin-clavulanic acid and Aspirin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competition for renal tubular organic anion secretion and plasma protein binding.
What to do
No routine dose change; monitor for amoxicillin adverse effects in patients with renal impairment or on high-dose aspirin.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amoxicillin-clavulanic acid
- Amoxicillin-clavulanic acid + Methotrexate Major
- Amoxicillin-clavulanic acid + Pexidartinib Major
- Amoxicillin-clavulanic acid + Pretomanid Major
- Allopurinol + Amoxicillin-clavulanic acid Moderate
- Amoxicillin-clavulanic acid + Bcg vaccine live Moderate
- Amoxicillin-clavulanic acid + Chloramphenicol Moderate
Frequently asked questions
Can I take Amoxicillin-clavulanic acid with Aspirin?
MediHelp rates the interaction as minor. Amoxicillin-clavulanic acid and Aspirin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Salicylates can compete with penicillins for renal tubular secretion and protein binding, which may modestly raise amoxicillin levels. The clinical effect is generally small given the wide therapeutic index of amoxicillin.
How serious is the interaction between Amoxicillin-clavulanic acid and Aspirin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change; monitor for amoxicillin adverse effects in patients with renal impairment or on high-dose aspirin.
What other medicines interact with Amoxicillin-clavulanic acid?
MediHelp also lists interactions of Amoxicillin-clavulanic acid with, for example, Methotrexate, Pexidartinib, Pretomanid. The full list is on the Amoxicillin-clavulanic acid page.
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