Drug interactions
Amoxicillin-clavulanic acid + Bcg vaccine live
Severity: Moderate
Amoxicillin-clavulanic acid and Bcg vaccine live: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Live BCG contains viable bacteria, and antibiotics active against them can reduce vaccine take. Amoxicillin has limited activity against BCG, but labeling for live bacterial vaccines advises avoiding concurrent antibiotics.
What this interaction means in plain words
Amoxicillin-clavulanic acid and Bcg vaccine live can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antibacterial activity may reduce replication of the live vaccine organism, lessening the immune response.
What to do
Defer BCG vaccination until antibiotic therapy is complete, where the vaccine is not urgent.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amoxicillin-clavulanic acid
- Amoxicillin-clavulanic acid + Methotrexate Major
- Amoxicillin-clavulanic acid + Pexidartinib Major
- Amoxicillin-clavulanic acid + Pretomanid Major
- Allopurinol + Amoxicillin-clavulanic acid Moderate
- Amoxicillin-clavulanic acid + Chloramphenicol Moderate
- Amoxicillin-clavulanic acid + Cholera vaccine Moderate
Frequently asked questions
Can I take Amoxicillin-clavulanic acid with Bcg vaccine live?
MediHelp rates the interaction as moderate. Amoxicillin-clavulanic acid and Bcg vaccine live can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Live BCG contains viable bacteria, and antibiotics active against them can reduce vaccine take. Amoxicillin has limited activity against BCG, but labeling for live bacterial vaccines advises avoiding concurrent antibiotics.
How serious is the interaction between Amoxicillin-clavulanic acid and Bcg vaccine live?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Defer BCG vaccination until antibiotic therapy is complete, where the vaccine is not urgent.
What other medicines interact with Amoxicillin-clavulanic acid?
MediHelp also lists interactions of Amoxicillin-clavulanic acid with, for example, Methotrexate, Pexidartinib, Pretomanid. The full list is on the Amoxicillin-clavulanic acid page.
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