Drug interactions
Amoxicillin-clavulanic acid + Pretomanid
Severity: Major
Amoxicillin-clavulanic acid and Pretomanid: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The pretomanid-containing regimen is associated with hepatotoxicity, and labeling advises avoiding other hepatotoxic agents. Amoxicillin-clavulanate can cause cholestatic or mixed liver injury. Concurrent use could raise the risk of serious hepatic injury.
What this interaction means in plain words
Amoxicillin-clavulanic acid and Pretomanid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amoxicillin-clavulanic acid belongs to Anti Bacterial; Pretomanid belongs to Anti Bacterial.
Why it happens
Additive hepatotoxicity from pretomanid-based therapy and clavulanate-associated liver injury.
What to do
Avoid amoxicillin-clavulanate during pretomanid therapy and select a less hepatotoxic antibiotic. If it cannot be avoided, monitor liver function tests frequently.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amoxicillin-clavulanic acid
- Amoxicillin-clavulanic acid + Methotrexate Major
- Amoxicillin-clavulanic acid + Pexidartinib Major
- Allopurinol + Amoxicillin-clavulanic acid Moderate
- Amoxicillin-clavulanic acid + Bcg vaccine live Moderate
- Amoxicillin-clavulanic acid + Chloramphenicol Moderate
- Amoxicillin-clavulanic acid + Cholera vaccine Moderate
Other interactions of Pretomanid
- Amiodarone + Pretomanid Major
- Amobarbital + Pretomanid Major
- Apalutamide + Pretomanid Major
- Armodafinil + Pretomanid Major
- Azathioprine + Pretomanid Major
- Bosentan + Pretomanid Major
Frequently asked questions
Can I take Amoxicillin-clavulanic acid with Pretomanid?
MediHelp rates the interaction as major. Amoxicillin-clavulanic acid and Pretomanid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. The pretomanid-containing regimen is associated with hepatotoxicity, and labeling advises avoiding other hepatotoxic agents. Amoxicillin-clavulanate can cause cholestatic or mixed liver injury. Concurrent use could raise the risk of serious hepatic injury.
How serious is the interaction between Amoxicillin-clavulanic acid and Pretomanid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid amoxicillin-clavulanate during pretomanid therapy and select a less hepatotoxic antibiotic. If it cannot be avoided, monitor liver function tests frequently.
What other medicines interact with Amoxicillin-clavulanic acid?
MediHelp also lists interactions of Amoxicillin-clavulanic acid with, for example, Methotrexate, Pexidartinib, Allopurinol. The full list is on the Amoxicillin-clavulanic acid page.
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