Drug interactions
Amoxicillin-clavulanic acid + Cholera vaccine
Severity: Moderate
Amoxicillin-clavulanic acid and Cholera vaccine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The oral live attenuated cholera vaccine relies on the vaccine strain colonizing the gut. Systemic antibiotics with activity against it may kill the strain and impair the immune response. Amoxicillin-clavulanate has activity against many Vibrio strains, so vaccine effectiveness could be reduced.
What this interaction means in plain words
Amoxicillin-clavulanic acid and Cholera vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antibacterial activity against the live attenuated Vibrio cholerae vaccine strain reduces its replication and immunogenicity.
What to do
Do not give the vaccine to patients who have taken systemic antibiotics in the preceding 14 days, per labeling. Avoid starting antibiotics for about 10 days after vaccination where possible, or revaccinate after the antibiotic course.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amoxicillin-clavulanic acid
- Amoxicillin-clavulanic acid + Methotrexate Major
- Amoxicillin-clavulanic acid + Pexidartinib Major
- Amoxicillin-clavulanic acid + Pretomanid Major
- Allopurinol + Amoxicillin-clavulanic acid Moderate
- Amoxicillin-clavulanic acid + Bcg vaccine live Moderate
- Amoxicillin-clavulanic acid + Chloramphenicol Moderate
Frequently asked questions
Can I take Amoxicillin-clavulanic acid with Cholera vaccine?
MediHelp rates the interaction as moderate. Amoxicillin-clavulanic acid and Cholera vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The oral live attenuated cholera vaccine relies on the vaccine strain colonizing the gut. Systemic antibiotics with activity against it may kill the strain and impair the immune response. Amoxicillin-clavulanate has activity against many Vibrio strains, so vaccine effectiveness could be reduced.
How serious is the interaction between Amoxicillin-clavulanic acid and Cholera vaccine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give the vaccine to patients who have taken systemic antibiotics in the preceding 14 days, per labeling. Avoid starting antibiotics for about 10 days after vaccination where possible, or revaccinate after the antibiotic course.
What other medicines interact with Amoxicillin-clavulanic acid?
MediHelp also lists interactions of Amoxicillin-clavulanic acid with, for example, Methotrexate, Pexidartinib, Pretomanid. The full list is on the Amoxicillin-clavulanic acid page.
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