Drug interactions
Amoxicillin-clavulanic acid + Choline magnesium trisalicylate
Severity: Minor
Amoxicillin-clavulanic acid and Choline magnesium trisalicylate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salicylates can reduce renal tubular secretion of penicillins, which may modestly raise amoxicillin concentrations. The clinical effect is usually small because amoxicillin has a wide therapeutic margin.
What this interaction means in plain words
Amoxicillin-clavulanic acid and Choline magnesium trisalicylate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Salicylates compete with amoxicillin for renal tubular organic anion secretion, reducing its clearance.
What to do
No routine dose change is needed; watch for amoxicillin adverse effects such as diarrhea or rash when high-dose salicylate therapy is used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amoxicillin-clavulanic acid
- Amoxicillin-clavulanic acid + Methotrexate Major
- Amoxicillin-clavulanic acid + Pexidartinib Major
- Amoxicillin-clavulanic acid + Pretomanid Major
- Allopurinol + Amoxicillin-clavulanic acid Moderate
- Amoxicillin-clavulanic acid + Bcg vaccine live Moderate
- Amoxicillin-clavulanic acid + Chloramphenicol Moderate
Frequently asked questions
Can I take Amoxicillin-clavulanic acid with Choline magnesium trisalicylate?
MediHelp rates the interaction as minor. Amoxicillin-clavulanic acid and Choline magnesium trisalicylate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Salicylates can reduce renal tubular secretion of penicillins, which may modestly raise amoxicillin concentrations. The clinical effect is usually small because amoxicillin has a wide therapeutic margin.
How serious is the interaction between Amoxicillin-clavulanic acid and Choline magnesium trisalicylate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; watch for amoxicillin adverse effects such as diarrhea or rash when high-dose salicylate therapy is used.
What other medicines interact with Amoxicillin-clavulanic acid?
MediHelp also lists interactions of Amoxicillin-clavulanic acid with, for example, Methotrexate, Pexidartinib, Pretomanid. The full list is on the Amoxicillin-clavulanic acid page.
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