Drug interactions
Amoxicillin-clavulanic acid + Demeclocycline
Severity: Moderate
Amoxicillin-clavulanic acid and Demeclocycline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
A bacteriostatic tetracycline may reduce the bactericidal action of penicillins in theory. Evidence is mainly in vitro and historical, with limited modern clinical confirmation. Concern is highest in severe or deep-seated infections.
What this interaction means in plain words
Amoxicillin-clavulanic acid and Demeclocycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism: inhibition of bacterial protein synthesis and growth lowers the activity of cell-wall-active beta-lactams.
What to do
Avoid using together for serious infections, and choose a single agent where feasible. If combined, monitor for treatment failure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amoxicillin-clavulanic acid
- Amoxicillin-clavulanic acid + Methotrexate Major
- Amoxicillin-clavulanic acid + Pexidartinib Major
- Amoxicillin-clavulanic acid + Pretomanid Major
- Allopurinol + Amoxicillin-clavulanic acid Moderate
- Amoxicillin-clavulanic acid + Bcg vaccine live Moderate
- Amoxicillin-clavulanic acid + Chloramphenicol Moderate
Frequently asked questions
Can I take Amoxicillin-clavulanic acid with Demeclocycline?
MediHelp rates the interaction as moderate. Amoxicillin-clavulanic acid and Demeclocycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. A bacteriostatic tetracycline may reduce the bactericidal action of penicillins in theory. Evidence is mainly in vitro and historical, with limited modern clinical confirmation. Concern is highest in severe or deep-seated infections.
How serious is the interaction between Amoxicillin-clavulanic acid and Demeclocycline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using together for serious infections, and choose a single agent where feasible. If combined, monitor for treatment failure.
What other medicines interact with Amoxicillin-clavulanic acid?
MediHelp also lists interactions of Amoxicillin-clavulanic acid with, for example, Methotrexate, Pexidartinib, Pretomanid. The full list is on the Amoxicillin-clavulanic acid page.
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