Drug interactions
Amoxicillin-clavulanic acid + Microbiota
Severity: Moderate
Amoxicillin-clavulanic acid and Microbiota: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral fecal microbiota spore products work by restoring gut flora after recurrent C. difficile infection. Residual antibiotics can kill the administered bacterial spores or the germinating organisms and reduce efficacy. Antibiotic exposure shortly before or during dosing is therefore undesirable.
What this interaction means in plain words
Amoxicillin-clavulanic acid and Microbiota can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antibacterial activity against the live bacterial content of the product impairs engraftment and colonization.
What to do
Complete antibiotic therapy and allow a washout interval, as stated in the product labeling, before giving the microbiota product. Do not give systemic antibiotics concurrently unless essential.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amoxicillin-clavulanic acid
- Amoxicillin-clavulanic acid + Methotrexate Major
- Amoxicillin-clavulanic acid + Pexidartinib Major
- Amoxicillin-clavulanic acid + Pretomanid Major
- Allopurinol + Amoxicillin-clavulanic acid Moderate
- Amoxicillin-clavulanic acid + Bcg vaccine live Moderate
- Amoxicillin-clavulanic acid + Chloramphenicol Moderate
Frequently asked questions
Can I take Amoxicillin-clavulanic acid with Microbiota?
MediHelp rates the interaction as moderate. Amoxicillin-clavulanic acid and Microbiota can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral fecal microbiota spore products work by restoring gut flora after recurrent C. difficile infection. Residual antibiotics can kill the administered bacterial spores or the germinating organisms and reduce efficacy. Antibiotic exposure shortly before or during dosing is therefore undesirable.
How serious is the interaction between Amoxicillin-clavulanic acid and Microbiota?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Complete antibiotic therapy and allow a washout interval, as stated in the product labeling, before giving the microbiota product. Do not give systemic antibiotics concurrently unless essential.
What other medicines interact with Amoxicillin-clavulanic acid?
MediHelp also lists interactions of Amoxicillin-clavulanic acid with, for example, Methotrexate, Pexidartinib, Pretomanid. The full list is on the Amoxicillin-clavulanic acid page.
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