Drug interactions
Amoxicillin-clavulanic acid + Mipomersen
Severity: Moderate
Amoxicillin-clavulanic acid and Mipomersen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both mipomersen and amoxicillin-clavulanic acid can raise liver enzymes, and clavulanate in particular is associated with cholestatic liver injury. Combined use may make liver injury harder to interpret or add to hepatotoxic risk.
What this interaction means in plain words
Amoxicillin-clavulanic acid and Mipomersen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hepatotoxic potential; mipomersen causes hepatic fat accumulation and transaminase elevation while clavulanate can cause idiosyncratic cholestatic hepatitis.
What to do
Check liver enzymes and bilirubin before and during the antibiotic course, and stop the antibiotic or reassess mipomersen if significant elevations occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amoxicillin-clavulanic acid
- Amoxicillin-clavulanic acid + Methotrexate Major
- Amoxicillin-clavulanic acid + Pexidartinib Major
- Amoxicillin-clavulanic acid + Pretomanid Major
- Allopurinol + Amoxicillin-clavulanic acid Moderate
- Amoxicillin-clavulanic acid + Bcg vaccine live Moderate
- Amoxicillin-clavulanic acid + Chloramphenicol Moderate
Frequently asked questions
Can I take Amoxicillin-clavulanic acid with Mipomersen?
MediHelp rates the interaction as moderate. Amoxicillin-clavulanic acid and Mipomersen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both mipomersen and amoxicillin-clavulanic acid can raise liver enzymes, and clavulanate in particular is associated with cholestatic liver injury. Combined use may make liver injury harder to interpret or add to hepatotoxic risk.
How serious is the interaction between Amoxicillin-clavulanic acid and Mipomersen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check liver enzymes and bilirubin before and during the antibiotic course, and stop the antibiotic or reassess mipomersen if significant elevations occur.
What other medicines interact with Amoxicillin-clavulanic acid?
MediHelp also lists interactions of Amoxicillin-clavulanic acid with, for example, Methotrexate, Pexidartinib, Pretomanid. The full list is on the Amoxicillin-clavulanic acid page.
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