Drug interactions
Amoxicillin-clavulanic acid + Mycophenolate
Severity: Moderate
Amoxicillin-clavulanic acid and Mycophenolate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amoxicillin-clavulanate has been associated with lower mycophenolic acid trough levels in transplant recipients. Reduced exposure could raise the risk of rejection, though the change may be modest and variable. The effect is attributed to altered gut flora.
What this interaction means in plain words
Amoxicillin-clavulanic acid and Mycophenolate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Reduction of gut bacterial beta-glucuronidase activity decreases deconjugation of mycophenolic acid glucuronide and so impairs enterohepatic recirculation.
What to do
Monitor for signs of graft rejection and consider mycophenolic acid level monitoring during and after the antibiotic course. Adjust the mycophenolate dose according to clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amoxicillin-clavulanic acid
- Amoxicillin-clavulanic acid + Methotrexate Major
- Amoxicillin-clavulanic acid + Pexidartinib Major
- Amoxicillin-clavulanic acid + Pretomanid Major
- Allopurinol + Amoxicillin-clavulanic acid Moderate
- Amoxicillin-clavulanic acid + Bcg vaccine live Moderate
- Amoxicillin-clavulanic acid + Chloramphenicol Moderate
Frequently asked questions
Can I take Amoxicillin-clavulanic acid with Mycophenolate?
MediHelp rates the interaction as moderate. Amoxicillin-clavulanic acid and Mycophenolate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amoxicillin-clavulanate has been associated with lower mycophenolic acid trough levels in transplant recipients. Reduced exposure could raise the risk of rejection, though the change may be modest and variable. The effect is attributed to altered gut flora.
How serious is the interaction between Amoxicillin-clavulanic acid and Mycophenolate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of graft rejection and consider mycophenolic acid level monitoring during and after the antibiotic course. Adjust the mycophenolate dose according to clinical response.
What other medicines interact with Amoxicillin-clavulanic acid?
MediHelp also lists interactions of Amoxicillin-clavulanic acid with, for example, Methotrexate, Pexidartinib, Pretomanid. The full list is on the Amoxicillin-clavulanic acid page.
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