Drug interactions
Amoxicillin-clavulanic acid + Salsalate
Severity: Minor
Amoxicillin-clavulanic acid and Salsalate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salsalate is a salicylate that may slightly reduce renal tubular secretion of penicillins, potentially raising amoxicillin exposure. The effect is generally small and of limited clinical importance.
What this interaction means in plain words
Amoxicillin-clavulanic acid and Salsalate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competition for renal tubular organic anion transport reduces amoxicillin clearance.
What to do
No dose adjustment is usually needed; monitor for amoxicillin adverse effects if high-dose salsalate is used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amoxicillin-clavulanic acid
- Amoxicillin-clavulanic acid + Methotrexate Major
- Amoxicillin-clavulanic acid + Pexidartinib Major
- Amoxicillin-clavulanic acid + Pretomanid Major
- Allopurinol + Amoxicillin-clavulanic acid Moderate
- Amoxicillin-clavulanic acid + Bcg vaccine live Moderate
- Amoxicillin-clavulanic acid + Chloramphenicol Moderate
Frequently asked questions
Can I take Amoxicillin-clavulanic acid with Salsalate?
MediHelp rates the interaction as minor. Amoxicillin-clavulanic acid and Salsalate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Salsalate is a salicylate that may slightly reduce renal tubular secretion of penicillins, potentially raising amoxicillin exposure. The effect is generally small and of limited clinical importance.
How serious is the interaction between Amoxicillin-clavulanic acid and Salsalate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed; monitor for amoxicillin adverse effects if high-dose salsalate is used.
What other medicines interact with Amoxicillin-clavulanic acid?
MediHelp also lists interactions of Amoxicillin-clavulanic acid with, for example, Methotrexate, Pexidartinib, Pretomanid. The full list is on the Amoxicillin-clavulanic acid page.
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