Drug interactions
Amoxicillin-clavulanic acid + Sodium picosulfate / magnesium oxide / anhydrous citric acid
Severity: Moderate
Amoxicillin-clavulanic acid and Sodium picosulfate / magnesium oxide / anhydrous citric acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sodium picosulfate is a prodrug that must be converted to its active laxative form by colonic bacteria. Antibiotics such as amoxicillin-clavulanic acid can suppress this flora and may reduce the quality of bowel cleansing before colonoscopy.
What this interaction means in plain words
Amoxicillin-clavulanic acid and Sodium picosulfate / magnesium oxide / anhydrous citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antibiotic-induced reduction of colonic bacteria impairs conversion of picosulfate to its active metabolite.
What to do
Where possible, avoid starting the antibiotic before bowel preparation; if unavoidable, assess cleansing adequacy and consider an alternative non-prodrug bowel preparation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amoxicillin-clavulanic acid
- Amoxicillin-clavulanic acid + Methotrexate Major
- Amoxicillin-clavulanic acid + Pexidartinib Major
- Amoxicillin-clavulanic acid + Pretomanid Major
- Allopurinol + Amoxicillin-clavulanic acid Moderate
- Amoxicillin-clavulanic acid + Bcg vaccine live Moderate
- Amoxicillin-clavulanic acid + Chloramphenicol Moderate
Frequently asked questions
Can I take Amoxicillin-clavulanic acid with Sodium picosulfate / magnesium oxide / anhydrous citric acid?
MediHelp rates the interaction as moderate. Amoxicillin-clavulanic acid and Sodium picosulfate / magnesium oxide / anhydrous citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sodium picosulfate is a prodrug that must be converted to its active laxative form by colonic bacteria. Antibiotics such as amoxicillin-clavulanic acid can suppress this flora and may reduce the quality of bowel cleansing before colonoscopy.
How serious is the interaction between Amoxicillin-clavulanic acid and Sodium picosulfate / magnesium oxide / anhydrous citric acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible, avoid starting the antibiotic before bowel preparation; if unavoidable, assess cleansing adequacy and consider an alternative non-prodrug bowel preparation.
What other medicines interact with Amoxicillin-clavulanic acid?
MediHelp also lists interactions of Amoxicillin-clavulanic acid with, for example, Methotrexate, Pexidartinib, Pretomanid. The full list is on the Amoxicillin-clavulanic acid page.
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