Drug interactions
Amoxicillin-clavulanic acid + Typhoid vaccine live
Severity: Moderate
Amoxicillin-clavulanic acid and Typhoid vaccine live: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral live typhoid vaccine (Ty21a) contains viable attenuated Salmonella Typhi, and antibiotics active against it may reduce its replication and immune response. Protection may be diminished if given during antibacterial therapy.
What this interaction means in plain words
Amoxicillin-clavulanic acid and Typhoid vaccine live can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antibacterial activity kills the attenuated vaccine organism before it can induce immunity.
What to do
Give the oral typhoid vaccine at least 24 hours after the last antibiotic dose, or delay vaccination until antibiotics are completed, per labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amoxicillin-clavulanic acid
- Amoxicillin-clavulanic acid + Methotrexate Major
- Amoxicillin-clavulanic acid + Pexidartinib Major
- Amoxicillin-clavulanic acid + Pretomanid Major
- Allopurinol + Amoxicillin-clavulanic acid Moderate
- Amoxicillin-clavulanic acid + Bcg vaccine live Moderate
- Amoxicillin-clavulanic acid + Chloramphenicol Moderate
Frequently asked questions
Can I take Amoxicillin-clavulanic acid with Typhoid vaccine live?
MediHelp rates the interaction as moderate. Amoxicillin-clavulanic acid and Typhoid vaccine live can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral live typhoid vaccine (Ty21a) contains viable attenuated Salmonella Typhi, and antibiotics active against it may reduce its replication and immune response. Protection may be diminished if given during antibacterial therapy.
How serious is the interaction between Amoxicillin-clavulanic acid and Typhoid vaccine live?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the oral typhoid vaccine at least 24 hours after the last antibiotic dose, or delay vaccination until antibiotics are completed, per labeling.
What other medicines interact with Amoxicillin-clavulanic acid?
MediHelp also lists interactions of Amoxicillin-clavulanic acid with, for example, Methotrexate, Pexidartinib, Pretomanid. The full list is on the Amoxicillin-clavulanic acid page.
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