Drug interactions
Amoxicillin-clavulanic acid + Willow bark
Severity: Minor
Amoxicillin-clavulanic acid and Willow bark: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Willow bark contains salicin, which is converted to salicylates. Salicylates may compete for renal tubular secretion of penicillins and slightly reduce their clearance. The effect is likely small at usual doses.
What this interaction means in plain words
Amoxicillin-clavulanic acid and Willow bark have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competition for renal tubular organic anion secretion between salicylates and amoxicillin.
What to do
No routine adjustment is needed. Be aware of the potential for higher amoxicillin exposure in patients with renal impairment or on high willow bark doses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amoxicillin-clavulanic acid
- Amoxicillin-clavulanic acid + Methotrexate Major
- Amoxicillin-clavulanic acid + Pexidartinib Major
- Amoxicillin-clavulanic acid + Pretomanid Major
- Allopurinol + Amoxicillin-clavulanic acid Moderate
- Amoxicillin-clavulanic acid + Bcg vaccine live Moderate
- Amoxicillin-clavulanic acid + Chloramphenicol Moderate
Frequently asked questions
Can I take Amoxicillin-clavulanic acid with Willow bark?
MediHelp rates the interaction as minor. Amoxicillin-clavulanic acid and Willow bark have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Willow bark contains salicin, which is converted to salicylates. Salicylates may compete for renal tubular secretion of penicillins and slightly reduce their clearance. The effect is likely small at usual doses.
How serious is the interaction between Amoxicillin-clavulanic acid and Willow bark?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Be aware of the potential for higher amoxicillin exposure in patients with renal impairment or on high willow bark doses.
What other medicines interact with Amoxicillin-clavulanic acid?
MediHelp also lists interactions of Amoxicillin-clavulanic acid with, for example, Methotrexate, Pexidartinib, Pretomanid. The full list is on the Amoxicillin-clavulanic acid page.
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