Drug interactions
Amphotericin b + Deflazacort
Severity: Moderate
Amphotericin b and Deflazacort: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs promote potassium loss, so combined use can cause clinically significant hypokalemia. Low potassium may lead to muscle weakness and cardiac arrhythmias, particularly in patients taking other QT-prolonging drugs.
What this interaction means in plain words
Amphotericin b and Deflazacort can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amphotericin b belongs to Anti Fungals; Deflazacort belongs to Miscellaneous.
Why it happens
Additive renal potassium wasting from amphotericin tubular toxicity and corticosteroid mineralocorticoid activity.
What to do
Monitor serum potassium and magnesium regularly and replace as needed. Consider ECG monitoring if levels are low or the patient has cardiac disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amphotericin b
- Amphotericin b + Cidofovir Contraindicated
- Adefovir + Amphotericin b Major
- Amikacin + Amphotericin b Major
- Amphotericin b + Arsenic trioxide Major
- Amphotericin b + Capreomycin Major
- Amphotericin b + Cephaloridine Major
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Amphotericin b with Deflazacort?
MediHelp rates the interaction as moderate. Amphotericin b and Deflazacort can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs promote potassium loss, so combined use can cause clinically significant hypokalemia. Low potassium may lead to muscle weakness and cardiac arrhythmias, particularly in patients taking other QT-prolonging drugs.
How serious is the interaction between Amphotericin b and Deflazacort?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium regularly and replace as needed. Consider ECG monitoring if levels are low or the patient has cardiac disease.
What other medicines interact with Amphotericin b?
MediHelp also lists interactions of Amphotericin b with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Amphotericin b page.
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