Drug interactions
Amphotericin b + Dexamethasone
Severity: Moderate
Amphotericin b and Dexamethasone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphotericin B wastes potassium through the kidney, and corticosteroids can further lower potassium. Combined use may cause marked hypokalemia, which can provoke arrhythmias and weakness, particularly in patients receiving digoxin or other QT-prolonging drugs.
What this interaction means in plain words
Amphotericin b and Dexamethasone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amphotericin b belongs to Anti Fungals; Dexamethasone belongs to Endocrine.
Why it happens
Additive renal potassium excretion from amphotericin B tubular toxicity and corticosteroid mineralocorticoid activity.
What to do
Check serum potassium and magnesium at baseline and regularly during therapy, and supplement as needed. Use ECG monitoring if levels are low or other arrhythmogenic drugs are given.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amphotericin b
- Amphotericin b + Cidofovir Contraindicated
- Adefovir + Amphotericin b Major
- Amikacin + Amphotericin b Major
- Amphotericin b + Arsenic trioxide Major
- Amphotericin b + Capreomycin Major
- Amphotericin b + Cephaloridine Major
Other interactions of Dexamethasone
- Bcg vaccine live + Dexamethasone Contraindicated
- Dexamethasone + Mifepristone Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexamethasone + Smallpox vaccine live Contraindicated
- Dexamethasone + Varicella virus vaccine live Contraindicated
- Dexamethasone + Yellow fever vaccine Contraindicated
Frequently asked questions
Can I take Amphotericin b with Dexamethasone?
MediHelp rates the interaction as moderate. Amphotericin b and Dexamethasone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amphotericin B wastes potassium through the kidney, and corticosteroids can further lower potassium. Combined use may cause marked hypokalemia, which can provoke arrhythmias and weakness, particularly in patients receiving digoxin or other QT-prolonging drugs.
How serious is the interaction between Amphotericin b and Dexamethasone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and magnesium at baseline and regularly during therapy, and supplement as needed. Use ECG monitoring if levels are low or other arrhythmogenic drugs are given.
What other medicines interact with Amphotericin b?
MediHelp also lists interactions of Amphotericin b with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Amphotericin b page.
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