Drug interactions
Amphotericin b + Foscarnet
Severity: Major
Amphotericin b and Foscarnet: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are nephrotoxic and can cause electrolyte disturbances such as hypokalemia and hypomagnesemia. Combined use increases the risk of renal impairment and metabolic derangements.
What this interaction means in plain words
Amphotericin b and Foscarnet can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amphotericin b belongs to Anti Fungals; Foscarnet belongs to Anti Virals.
Why it happens
Additive nephrotoxicity and electrolyte wasting.
What to do
Avoid concurrent use if alternatives exist; if needed, ensure hydration and monitor creatinine, potassium, magnesium and calcium frequently.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Amphotericin b
- Amphotericin b + Cidofovir Contraindicated
- Adefovir + Amphotericin b Major
- Amikacin + Amphotericin b Major
- Amphotericin b + Arsenic trioxide Major
- Amphotericin b + Capreomycin Major
- Amphotericin b + Cephaloridine Major
Other interactions of Foscarnet
- Cidofovir + Foscarnet Contraindicated
- Foscarnet + Pimozide Contraindicated
- Foscarnet + Thioridazine Contraindicated
- Foscarnet + Vandetanib Contraindicated
- Adagrasib + Foscarnet Major
- Adefovir + Foscarnet Major
Frequently asked questions
Can I take Amphotericin b with Foscarnet?
MediHelp rates the interaction as major. Amphotericin b and Foscarnet can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents are nephrotoxic and can cause electrolyte disturbances such as hypokalemia and hypomagnesemia. Combined use increases the risk of renal impairment and metabolic derangements.
How serious is the interaction between Amphotericin b and Foscarnet?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use if alternatives exist; if needed, ensure hydration and monitor creatinine, potassium, magnesium and calcium frequently.
What other medicines interact with Amphotericin b?
MediHelp also lists interactions of Amphotericin b with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Amphotericin b page.
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