Drug interactions
Amphotericin b + Ifosfamide
Severity: Major
Amphotericin b and Ifosfamide: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are nephrotoxic, and ifosfamide commonly causes proximal tubular injury, so combined exposure can worsen kidney damage. Electrolyte wasting may also be amplified.
What this interaction means in plain words
Amphotericin b and Ifosfamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amphotericin b belongs to Anti Fungals; Ifosfamide belongs to Oncology.
Why it happens
Additive nephrotoxicity affecting renal tubules.
What to do
Avoid the combination where possible, or monitor serum creatinine, electrolytes and urine output frequently. Ensure adequate hydration and consider lipid or liposomal amphotericin if therapy is needed.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Amphotericin b
- Amphotericin b + Cidofovir Contraindicated
- Adefovir + Amphotericin b Major
- Amikacin + Amphotericin b Major
- Amphotericin b + Arsenic trioxide Major
- Amphotericin b + Capreomycin Major
- Amphotericin b + Cephaloridine Major
Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Frequently asked questions
Can I take Amphotericin b with Ifosfamide?
MediHelp rates the interaction as major. Amphotericin b and Ifosfamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs are nephrotoxic, and ifosfamide commonly causes proximal tubular injury, so combined exposure can worsen kidney damage. Electrolyte wasting may also be amplified.
How serious is the interaction between Amphotericin b and Ifosfamide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or monitor serum creatinine, electrolytes and urine output frequently. Ensure adequate hydration and consider lipid or liposomal amphotericin if therapy is needed.
What other medicines interact with Amphotericin b?
MediHelp also lists interactions of Amphotericin b with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Amphotericin b page.
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