Drug interactions
Amphotericin b + Mechlorethamine
Severity: Moderate
Amphotericin b and Mechlorethamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can harm the kidneys, and concurrent use may increase the risk of renal impairment. Reports have also described bronchospasm and hypotension with this combination.
What this interaction means in plain words
Amphotericin b and Mechlorethamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amphotericin b belongs to Anti Fungals; Mechlorethamine belongs to Oncology.
Why it happens
Additive nephrotoxicity; the mechanism for the bronchospasm and hypotension is not well established.
What to do
Monitor renal function, blood pressure and respiratory status during co-treatment. Ensure adequate hydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amphotericin b
- Amphotericin b + Cidofovir Contraindicated
- Adefovir + Amphotericin b Major
- Amikacin + Amphotericin b Major
- Amphotericin b + Arsenic trioxide Major
- Amphotericin b + Capreomycin Major
- Amphotericin b + Cephaloridine Major
Other interactions of Mechlorethamine
Frequently asked questions
Can I take Amphotericin b with Mechlorethamine?
MediHelp rates the interaction as moderate. Amphotericin b and Mechlorethamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can harm the kidneys, and concurrent use may increase the risk of renal impairment. Reports have also described bronchospasm and hypotension with this combination.
How serious is the interaction between Amphotericin b and Mechlorethamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function, blood pressure and respiratory status during co-treatment. Ensure adequate hydration.
What other medicines interact with Amphotericin b?
MediHelp also lists interactions of Amphotericin b with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Amphotericin b page.
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