Drug interactions
Amphotericin b + Rituximab
Severity: Moderate
Amphotericin b and Rituximab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphotericin B is nephrotoxic, and rituximab can cause acute kidney injury, especially in tumor lysis syndrome. Using them together may increase the risk of renal impairment, and both can cause infusion reactions with hypotension.
What this interaction means in plain words
Amphotericin b and Rituximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amphotericin b belongs to Anti Fungals; Rituximab belongs to Musculoskeletal.
Why it happens
Additive renal toxicity; rituximab effects relate to tumor lysis and infusion reactions rather than direct tubular injury.
What to do
Monitor renal function, electrolytes and blood pressure during and after infusions, and keep patients well hydrated. Space infusions and consider a lipid-based amphotericin formulation if renal function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amphotericin b
- Amphotericin b + Cidofovir Contraindicated
- Adefovir + Amphotericin b Major
- Amikacin + Amphotericin b Major
- Amphotericin b + Arsenic trioxide Major
- Amphotericin b + Capreomycin Major
- Amphotericin b + Cephaloridine Major
Other interactions of Rituximab
Frequently asked questions
Can I take Amphotericin b with Rituximab?
MediHelp rates the interaction as moderate. Amphotericin b and Rituximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amphotericin B is nephrotoxic, and rituximab can cause acute kidney injury, especially in tumor lysis syndrome. Using them together may increase the risk of renal impairment, and both can cause infusion reactions with hypotension.
How serious is the interaction between Amphotericin b and Rituximab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function, electrolytes and blood pressure during and after infusions, and keep patients well hydrated. Space infusions and consider a lipid-based amphotericin formulation if renal function declines.
What other medicines interact with Amphotericin b?
MediHelp also lists interactions of Amphotericin b with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Amphotericin b page.
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