Drug interactions
Amphotericin b + Rocuronium
Severity: Moderate
Amphotericin b and Rocuronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphotericin B can cause hypokalemia and other electrolyte disturbances such as hypomagnesemia. These disturbances can enhance and prolong the neuromuscular blockade from rocuronium, increasing the risk of prolonged paralysis and respiratory depression.
What this interaction means in plain words
Amphotericin b and Rocuronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amphotericin b belongs to Anti Fungals; Rocuronium belongs to Musculoskeletal.
Why it happens
Amphotericin B-induced hypokalemia and hypomagnesemia potentiate non-depolarizing neuromuscular blockade (indirect pharmacodynamic synergism).
What to do
Check and correct serum potassium and magnesium before and during anesthesia. Monitor neuromuscular function with train-of-four and be prepared for prolonged ventilatory support.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amphotericin b
- Amphotericin b + Cidofovir Contraindicated
- Adefovir + Amphotericin b Major
- Amikacin + Amphotericin b Major
- Amphotericin b + Arsenic trioxide Major
- Amphotericin b + Capreomycin Major
- Amphotericin b + Cephaloridine Major
Other interactions of Rocuronium
Frequently asked questions
Can I take Amphotericin b with Rocuronium?
MediHelp rates the interaction as moderate. Amphotericin b and Rocuronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amphotericin B can cause hypokalemia and other electrolyte disturbances such as hypomagnesemia. These disturbances can enhance and prolong the neuromuscular blockade from rocuronium, increasing the risk of prolonged paralysis and respiratory depression.
How serious is the interaction between Amphotericin b and Rocuronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check and correct serum potassium and magnesium before and during anesthesia. Monitor neuromuscular function with train-of-four and be prepared for prolonged ventilatory support.
What other medicines interact with Amphotericin b?
MediHelp also lists interactions of Amphotericin b with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Amphotericin b page.
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