Drug interactions
Amphotericin b + Valganciclovir
Severity: Moderate
Amphotericin b and Valganciclovir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valganciclovir is converted to ganciclovir, which can suppress bone marrow and affect the kidney, as can amphotericin B. Combined use may increase nephrotoxicity and cytopenias, and renal impairment raises ganciclovir exposure.
What this interaction means in plain words
Amphotericin b and Valganciclovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amphotericin b belongs to Anti Fungals; Valganciclovir belongs to Anti Virals.
Why it happens
Additive nephrotoxicity and myelosuppression, with reduced ganciclovir clearance when renal function declines.
What to do
Monitor creatinine and blood counts regularly, and adjust the valganciclovir dose to creatinine clearance.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amphotericin b
- Amphotericin b + Cidofovir Contraindicated
- Adefovir + Amphotericin b Major
- Amikacin + Amphotericin b Major
- Amphotericin b + Arsenic trioxide Major
- Amphotericin b + Capreomycin Major
- Amphotericin b + Cephaloridine Major
Other interactions of Valganciclovir
Frequently asked questions
Can I take Amphotericin b with Valganciclovir?
MediHelp rates the interaction as moderate. Amphotericin b and Valganciclovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valganciclovir is converted to ganciclovir, which can suppress bone marrow and affect the kidney, as can amphotericin B. Combined use may increase nephrotoxicity and cytopenias, and renal impairment raises ganciclovir exposure.
How serious is the interaction between Amphotericin b and Valganciclovir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor creatinine and blood counts regularly, and adjust the valganciclovir dose to creatinine clearance.
What other medicines interact with Amphotericin b?
MediHelp also lists interactions of Amphotericin b with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Amphotericin b page.
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