Drug interactions
Amphotericin b cholesteryl + Benazepril
Severity: Moderate
Amphotericin b cholesteryl and Benazepril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphotericin B is nephrotoxic and can cause volume depletion and renal impairment. Combined with benazepril, renal function may decline further and hyperkalemia or hypokalemia can complicate management. Hypotension is not a typical direct effect of the interaction.
What this interaction means in plain words
Amphotericin b cholesteryl and Benazepril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Amphotericin-induced renal vasoconstriction and tubular injury combined with ACE inhibitor loss of efferent arteriolar tone can reduce glomerular filtration.
What to do
Monitor creatinine and electrolytes frequently during therapy, and ensure adequate hydration. Consider temporarily holding benazepril if renal function worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Frequently asked questions
Can I take Amphotericin b cholesteryl with Benazepril?
MediHelp rates the interaction as moderate. Amphotericin b cholesteryl and Benazepril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amphotericin B is nephrotoxic and can cause volume depletion and renal impairment. Combined with benazepril, renal function may decline further and hyperkalemia or hypokalemia can complicate management. Hypotension is not a typical direct effect of the interaction.
How serious is the interaction between Amphotericin b cholesteryl and Benazepril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor creatinine and electrolytes frequently during therapy, and ensure adequate hydration. Consider temporarily holding benazepril if renal function worsens.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Benazepril page.
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